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The mu-opioid receptor is encoded by the Oprm1 gene and contributes to mother—infant behaviors. Rodent dams lick male pups more than female pups in the anogenital region. This behavior is linked to stress responsivity in the offspring that may be mediated by epigenetic changes. We hypothesized that maternal behavior may affect DNA methylation levels of the Oprm1 gene and show sex differences. To further explore sex differences in mother—pup behaviors and DNA methylation levels, we altered the litter gender composition LGC of rats.
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